After the death of Alexander the Great Syria was a part of Seleucia. Persons from Seleucia Seleucus I Nicator, Antiochus I Soter, Antiochus II Theos, Seleucus II Callinicus, Seleucus III Soter, Antiochus III the Great, Antiochus IV Epiphanes Romans involved Lucius Scipio Events: The start of the Maccabee rebellion (167-164 BC) Death of Jonathan Maccabaeus (143 BC) Peace of Simon Maccabaeus and Demetrius (142 BC) War of Alexander Jannaeus and Demetrius II (88 BC) Battle of Sichem (88 BC)
In Roman times its name became Syria.
In the 3rd century it became very powerful under the reign of Odaenathus, Zenobia, and Vaballatus in Palmyra.
Links: Syria Gate